Oklahoma's Orthobiologic PRP Authority
Before You Pay $$$ for PRP,
Get Straight Answers
Not every PRP is the same. Most clinics that "do PRP" can't answer the five questions on this page. We can.
Not every PRP is the same. Most clinics that "do PRP" can't answer the five questions on this page. We can.
In Oklahoma today, PRP injections are offered at urgent care clinics, med spas, chiropractors' offices, and pain management practices. Every one of them will tell you it's the same thing. It isn't.
PRP — platelet-rich plasma — works by concentrating the growth factors and healing proteins from your own blood and delivering them precisely to damaged tissue. The critical word is precisely. Precision requires three things most clinics don't have: a verified platelet concentration, a tissue-specific protocol, and image-guided delivery.
Without those three things, you may be paying a premium price for a vial of mildly concentrated blood and a blind injection. That's not PRP. That's a clinic pretending to understand PRP to capitalize on the growing public awareness of PRP as a medically researched orthopedic and musculoskeletal treatment option.
"If a clinic can't tell you how many platelets are in the syringe, they don't know what they're injecting. That's not a small detail — it's critical to the success of the treatment."
— Keley John Booth, MD, D.ABA · OrthobiogenImagine you walk into two pharmacies. At the first, the pharmacist measures your prescription precisely, tailors the dose to your weight and kidney function, and hands you labeled medication. At the second, they say, "Oh, we do medication" — and hand you something in an unlabeled syringe because they don't have a scale. Both call themselves a pharmacy. Would you use the second one for something you're injecting into your body?
These questions are not trick questions. An Orthopedic or Musculoskeletal specialist that has done this work at a serious level will answer all five immediately — with specifics. A clinic that uses PRP as an add-on revenue item will not.
Platelet concentration is the foundation of PRP efficacy. Research supports specific therapeutic windows — too low and there's minimal benefit, too high and you may trigger the wrong kind of inflammation. A qualified provider should give you a specific number (e.g., 10 billion platelets for an intra-articular knee injection) and explain how their system verifies it.
Red flag: "We concentrate your platelets" — without a specific concentration number.A ligament needs a different concentration than a joint surface. A joint surface needs a different concentration than a spinal disc. An 18 year old patient requires a significantly lower concentration than a 75 year old. One-size-fits-all PRP is a sign of a one-size-fits-all protocol — meaning no protocol at all. Tissue-specific dosing is a marker of serious regenerative practice.
Red flag: "We use the same kit for everything."Studies show that Orthopedic surgeons using unguided ("blind") injection techniques into the knee joint miss their target about 1 in 5 times. That means 20% of the time, the PRP you paid for goes into the wrong tissue. All injections at Orthobiogen are performed under ultrasound or fluoroscopic guidance — in real time, verified on screen.
Red flag: "We use anatomical landmarks" for a joint injection.Not all PRP preparations processes are equal. The processing protocols, equipment, and staff training determines platelet yield, purity, and biological activity. Ask for the specific device or protocol by name. Ask what data they have on outcomes for the specific procedure they are performing. A clinic operating at the leading edge of regenerative medicine can answer this — and will be eager to.
Red flag: Vague answers about "our machine" or "a special process."Regenexx maintains the nation's largest outcomes registry for orthobiologic treatments — more than 86,000 tracked patients across nine body regions, including 26,000+ knee, 21,000+ lumbar spine, and 11,000+ shoulder patients. Certified providers follow rigorously validated protocols, not improvised ones. Certification requires demonstrated training, proper equipment, and ongoing outcomes reporting. It is not a marketing badge. It is an accountability system.
Red flag: "We follow a similar approach" — but no certification.NSAIDs (ibuprofen, naproxen) block the prostaglandin pathways that PRP relies on to trigger healing. They should be stopped two weeks before a PRP procedure. Steroids must be out of your system for at least four weeks. And — critically — lidocaine should never be injected into a joint cavity. It is directly toxic to cartilage cells. Most providers don't know this. Ask anyway.
Watch for: lidocaine added to PRP "for comfort."| Standard | Typical PRP Clinic | Orthobiogen |
|---|---|---|
| Platelet count verified | ✗ Estimated or unknown | ✓ Measured and documented per injection |
| Tissue-specific concentration | ✗ Same kit, same dose | ✓ Widest range of concentrations matched to tissue type & damage level |
| Image guidance | ✗ Blind or landmark-based | ✓ 100% ultrasound or fluoroscopic guidance |
| Processing technology | ✗ Generic centrifuge | ✓ Specially trained and certified staff, protocols, & equipment |
| Outcomes tracking | ✗ None | ✓ Regenexx National Registry — 86,000+ patients |
| Provider certification | ✗ No independent validation | ✓ Regenexx-certified provider |
| Joint-safe anesthesia | ✗ Lidocaine often added intra-articularly | ✓ Never — lidocaine is toxic to cartilage cells |
| Pre-procedure protocol | ✗ Walk in, get injected | ✓ NSAID washout, steroid clearance, medical review |
In any form of medicine, the dose matters. PRP researchers have identified therapeutic windows for joint tissue — below which you see no meaningful effect, above which you risk excess inflammation. A clinic that doesn't measure concentration isn't dosing your treatment. They're guessing. We deliver 10 billion platelets to a knee joint. That's not a claim. It's a measurement.
Ligaments, joint surfaces, joint capsules, and spinal discs all have different vascular supply, different cell populations, and different healing mechanisms. Our protocols use concentrations calibrated for each tissue type and damage level. True Orthobiologic and Regenerative Specialists use wide ranges of concentrations from 3X to 20X+, as well as varying preparations including platelet lysates and orthobiologic prolotherapy preparations with PRP. A single-kit approach ignores this biology entirely.
Published studies on intra-articular knee injections without image guidance show miss rates of 20% or higher. That means one in five patients who paid for PRP had it injected into periarticular tissue — outside the joint. No benefit, full cost. Image guidance is not optional. It is the standard of care. Every injection we perform is confirmed on screen in real time before the solution is released.
Lidocaine is directly toxic to chondrocytes — the cells that maintain cartilage. Adding it to an intra-articular PRP injection to "numb the knee" is counterproductive at best and destructive at worst. We have not used intra-articular lidocaine in over a decade. Subcutaneous local anesthetic is used for skin comfort — but it never enters the joint. Most PRP providers have never considered this distinction. We have.
The strength of an outcomes registry is its scale. The Regenexx® Provider Patient Registry tracks patient progress across nine body regions — more than 86,000 patients in total. Certified providers contribute to and are measured against this data.
Source: Regenexx® Provider Patient Registry, regenexx.com/results — figures reflect tracked patients and update over time.
Before we ever discuss PRP as a treatment option, you'll receive a comprehensive evaluation — physical exam, diagnostic ultrasound performed in-office, and a review of your imaging. We grade your candidacy explicitly: good, fair, or poor. If PRP is not likely to help you, we tell you directly. We do not recommend treatments on patients who aren't appropriate candidates for regenerative orthobiologic treatments.
If you are a good candidate, we'll explain exactly what we'll inject, at what concentration, into which structures, and why. You'll see the process on screen. You'll understand the recovery. You'll have a specific 12-week timeline for evaluating your outcome.
If you've already had PRP somewhere else and didn't get results, that's worth discussing. In many cases, failed PRP was a delivery problem, not a biology problem.
"I wouldn't do anything to you that I wouldn't do to myself. The same protocols I use on my own family are what I offer every patient. That's the standard I work by."
— Keley John Booth, MD, D.ABA · OrthobiogenPricing is reasonable and fully transparent from the first conversation. Our Board-Certified Physician experts deliver the lowest cost per PRP dose in Oklahoma — without compromising on platelet concentration, image guidance, or protocol. Insurance does not cover orthobiologic procedures (they are classified as experimental, despite more than 86,000 tracked patient outcomes showing safety and benefit), so we make the math straightforward. Payment plans are available.
A lower sticker price does not always mean a lower cost. With PRP, what you are paying for is the platelets delivered to your tissue — so the only honest way to compare two clinics is dollars per platelet, not dollars per visit. A clinic can advertise a cheaper procedure and still cost you more once you account for what is actually in the syringe.
That is the comparison we will make for you. Bring us a verified price offer from any Oklahoma-based musculoskeletal or orthopedic PRP provider, and we will match it on a dollar-per-platelet basis.
From that documentation, we calculate the true number of platelets the competing procedure would deliver, divide by its price, and match that dollar-per-platelet rate for your equivalent treatment at Orthobiogen. It is the same standard we hold ourselves to throughout this page: in PRP, the number is the treatment.
Call us, bring your imaging, and ask us the five questions. We'll give you specific answers — not marketing language. If you're not a good candidate, we'll tell you that too.